Although skin is routinely grown outside the human body and grafted onto living patients, an entire heart, for instance, has not yet been grown in a lab dish.
But MIT researchers have developed a new scaffold with the goal of seeding living heart cells or stem cells that would develop into a patch of cardiac tissue that could be used to treat congenital heart defects, or aid the recovery of tissue damaged by a heart attack. The biodegradable scaffold would be gradually absorbed into the body, leaving behind new tissue.
The accordion-like honeycomb scaffold developed by researchers in the Harvard-MIT Division of Health Sciences and Technology and Draper Laboratory is the first to be explicitly designed to match the structural and mechanical properties of native heart tissue. As a result, it has several advantages over previous cardiac tissue engineering scaffolds.
The team hopes to generate “a whole library of scaffolds for different tissues in need of repair,” said Lisa E. Freed, principal research scientist on the work. – Deborah Halber